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Research peptides2 specifications

Gonadorelin

COA on request

Gonadorelin: A peptide that helps support natural testosterone production by stimulating the release of two key hormones — LH (luteinizing hormone) and FSH (follicle-stimulating hormone). These hormones signal the testes to produce more testosterone, which can be useful for those looking to maintain healthy hormone levels, particularly after cycles of exogenous androgen use. It's often used in hormone therapy and fertility support.

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GND2
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2 mg x 10 vials
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Purity≥98%Estimated delivery: within one week after the order is placed.
COA is available on request

COA files are available in the document library; additional batch-specific documentation can be requested with your inquiry. Each batch is tested with HPLC purity analysis (≥98%). For MSDS or detailed storage protocols, please contact our sales team.

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Research effects

Gonadorelin (gonadotropin-releasing hormone) is a naturally occurring hypothalamic decapeptide that plays a central role in reproductive endocrine regulation. Clinically, Gonadorelin is widely used as a diagnostic test (e.g., pituitary stimulation test) to evaluate pituitary gonadotropin reserve function, distinguishing between hypothalamic and pituitary hypogonadism. In therapeutic applications, exogenous administration of Gonadorelin or its analogues effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby inducing follicle maturation and ovulation or promoting spermatogenesis. Furthermore, it is utilized in assisted reproductive technology (ART) for precisely timing ovulation to enhance conception success rates.

Research mechanism

Gonadorelin exerts its effects by binding to specific GnRH receptors (GnRHR) on pituitary gonadotroph cells. These receptors belong to the G protein-coupled receptor family. Receptor activation initiates the phospholipase C (PLC)/inositol trisphosphate (IP3)/diacylglycerol (DAG) signaling pathway, promoting intracellular calcium release and consequently stimulating LH and FSH synthesis and pulsatile secretion. Its secretion exhibits distinct pulsatile rhythmicity, with variations in pulse frequency and amplitude determining pituitary responsiveness to gonadal signals. Upon continuous high-dose administration, receptor downregulation and desensitization occur—a mechanism exploited therapeutically to inhibit the progression of sex hormone-dependent conditions such as prostate cancer and endometriosis.

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GND22 mg x 10 vials