Research peptides2 specifications

KissPeptin-10

Name: KissPeptin-10
Brand: SUN Peptides
SKU: KS5

COA on request

KissPeptin-10: A peptide that plays a key role in regulating the reproductive hormone axis. It works by stimulating the release of gonadotropin-releasing hormone (GnRH), which in turn supports the natural production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) — two hormones essential for reproductive health. It has gained interest in research settings for its potential to support hormonal balance and fertility.

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Selected SKU: KS5
Pack: 5 mg x 10 vials
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Purity≥99%Estimated delivery: within one week after the order is placed.

COA is available on request

COA files are available in the document library; additional batch-specific documentation can be requested with your inquiry. Each batch is tested with HPLC purity analysis (≥99%). For MSDS or detailed storage protocols, please contact our sales team.

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Research effects

Kisspeptin-10 is the C-terminal bioactive decapeptide fragment of the Kisspeptin protein, playing a central regulatory role in controlling the hypothalamic-pituitary-gonadal (HPG) axis and gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin-10 possesses potent gonadotropin-releasing capacity and has been investigated for treating delayed puberty, functional hypothalamic amenorrhea, male hypogonadism, and infertility. It effectively stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, promoting gonadal maturation, follicular development, and spermatogenesis. Additionally, Kisspeptin-10 demonstrates potential in mood regulation and the neural regulation of reproductive behavior.

Research mechanism

Kisspeptin-10 acts by binding to the G protein-coupled receptor GPR54 (KISS1R) on hypothalamic GnRH neurons. This binding activates the Gq/11 signaling pathway, increasing intracellular calcium concentration and MAPK/ERK phosphorylation, promoting pulsatile GnRH release. GnRH subsequently stimulates LH and FSH secretion from the anterior pituitary. Kisspeptin-10 bidirectionally regulates HPG axis function through both positive feedback (estrogen-induced preovulatory LH surge) and negative feedback (sex hormone-mediated inhibition of GnRH). This peptide also enhances hypothalamic integration of metabolic signals (including leptin and ghrelin) through regulation of GnRH neuronal excitability and synaptic plasticity, coordinating reproduction with energy status.

Product details

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KS55 mg x 10 vials