Research effects
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminus of α-melanocyte-stimulating hormone (α-MSH), demonstrating significant anti-inflammatory and immunomodulatory activities. In preclinical and
Catalogue
Research peptides1 specification
KPV
COA on requestKPV: Strong anti-inflammatory action that supports gut and skin repair. It is a peptide derived from a natural protein, known for its ability to modulate immune response and reduce inflammation. It is often used to support digestive health and skin conditions, particularly where inflammation is a key factor.
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Purity≥99%Estimated delivery: within one week after the order is placed.
COA is available on request
COA files are available in the document library; additional batch-specific documentation can be requested with your inquiry. Each batch is tested with HPLC purity analysis (≥99%). For MSDS or detailed storage protocols, please contact our sales team.
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DeliveryWithin one week after order
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DocumentationCOA available on request
Efficacy
clinical studies, KPV shows protective effects in reducing severity of inflammatory conditions including dermatitis, psoriasis, colitis, and ocular inflammation. Its anti-inflammatory potency is robust, modulating the inflammatory microenvironment through multiple mechanisms without significant cytotoxicity or immunosuppressive effects. Additionally, KPV has drawn attention for its potential tissue-protective and antioxidant properties.
Research mechanism
KPV exerts anti-inflammatory effects through multiple pathways. It activates melanocortin receptors (MCRs), subsequently inhibiting NF-κB signaling nuclear translocation and reducing transcriptional levels of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, and IL-8, while upregulating anti-inflammatory cytokine IL-10 expression. Furthermore, KPV inhibits excessive activation of neutrophils and macrophages, reducing oxidative stress damage at inflammatory sites. In autoimmune inflammatory models, KPV demonstrates negative regulation of effector T cell proliferation and differentiation, promoting establishment of local immune tolerance environments.
Product details
Key identity and handling information for the selected research material.
Material identity
As a very short peptide, identity confirmation should include sequence-specific mass data in addition to chromatographic purity.
Storage guidance
Store unopened material in its original sealed packaging, protected from light, moisture, and repeated temperature changes. Follow the product label and batch document for the exact storage temperature. After opening or preparation, use only a validated laboratory storage protocol.
Quality review
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Resolution
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