Research peptides3 specifications

MOTS-c

Name: MOTS-c
Brand: SUN Peptides
SKU: MS5

COA on request

MOTS-c: A mitochondrial peptide that supports energy metabolism and improves endurance. It's a naturally occurring peptide encoded by mitochondrial DNA, which is unusual — most peptides are encoded by nuclear DNA. It works by regulating glucose and fat metabolism, helping your body use energy more efficiently. In research settings, it's been shown to improve insulin sensitivity and increase physical performance. Often studied for its potential role in metabolic health, longevity, and exercise endurance.

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Selected SKU: MS5
Pack: 5 mg x 10 vials
Status: Available for inquiry

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Purity≥99%Estimated delivery: within one week after the order is placed.

COA is available on request

COA files are available in the document library; additional batch-specific documentation can be requested with your inquiry. Each batch is tested with HPLC purity analysis (≥99%). For MSDS or detailed storage protocols, please contact our sales team.

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DeliveryWithin one week after order

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DocumentationCOA available on request

Research effects

MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame of the mitochondrial 12S rRNA gene, which translocates to the nucleus upon stress or exercise stimulation to regulate gene transcription. Its core mechanism involves modulating energy metabolism, insulin sensitivity, and inflammatory responses primarily via the Folate-AICAR-AMPK pathway. Preclinically, MOTS-c attenuates myocardial ischemia-reperfusion injury and hypoxia/reoxygenation-induced cardiomyocyte damage by upregulating PGC-1α-mediated mitochondrial biogenesis. A Phase 2a randomized double-blind trial is currently evaluating its efficacy in improving insulin sensitivity in adults with prediabetes and overweight/obesity. Importantly, MOTS-c is not FDA-approved for any clinical indication; commercially available products pose quality and safety risks, warranting caution.

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MS55 mg x 10 vials