Research effects
MT-2 (Melanotan II) is a synthetic cyclic peptide and melanocortin receptor (MC1R, MC3R, MC4R) agonist. Its core mechanism involves activating MC1R to stimulate melanogenesis for skin tanning, while central MC4R activation mediates pro-erectile and aphrodisiac effects. It was investigated as a tanning agent and treatment for sexual dysfunction but failed to gain regulatory approval due to safety concerns including nausea, flushing, blood pressure fluctuations, and potential melanoma risk. Currently marketed as a "research chemical" in some countries, MT-2 lacks approved safety and efficacy data and is subject to monitoring in anti-doping and illicit substance surveillance programs in multiple jurisdictions.




