Research effects
P21 (here referring to P021 peptide, sequence Ac-DGGLAG-NH₂) is a small-molecule peptidergic compound derived from ciliary neurotrophic factor (CNTF), demonstrating neuroprotective and cognitive-enhancing potential in preclinical studies. Its core mechanism involves promoting BDNF expression and enhancing synaptic plasticity, improving cognitive and motor functions in models of Alzheimer's disease and CDKL5 deficiency disorder. P021 remains in the preclinical research stage without clinical approval, and its efficacy and safety require further validation.




