Catalogue
Proteins and hormones2 specifications

IGF-1LR3

COA on request

Long R3 IGF-1 is an engineered insulin-like growth factor analogue with an N-terminal extension and an Arg substitution at position 3. Available microgram specifications are grouped on one page.

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IGF-01
Pack
0.1 mg x 10 vials
Status
Available for inquiry

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Purity≥98%Estimated delivery: within one week after the order is placed.
COA is available on request

COA files are available in the document library; additional batch-specific documentation can be requested with your inquiry. Each batch is tested with HPLC purity analysis (≥98%). For MSDS or detailed storage protocols, please contact our sales team.

Order formatOne box accepted
DeliveryWithin one week after order
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DocumentationCOA available on request

Research effects

Insulin-like growth factor-1 LR3 (IGF-1 LR3) is a long-acting analogue of IGF-1, engineered by substituting arginine for glutamic acid at position 3 and extending the N-terminal sequence by 13 amino acids, resulting in significantly enhanced biological activity. This peptide demonstrates potent effects in promoting muscle hypertrophy, increasing lean body mass, and accelerating tissue repair, with users reporting effective muscle growth and recovery. In preclinical studies, IGF-1 LR3 has been shown to stimulate proliferation and differentiation of multiple cell types and demonstrate potential in improving functional recovery following nerve injury.

Research mechanism

IGF-1 LR3 binds with high affinity to the IGF-1 receptor (IGF-1R), activating downstream PI3K/Akt and MAPK/ERK signaling pathways to promote protein synthesis and inhibit protein degradation, thereby driving muscle hypertrophy and cell proliferation. Its key structural advantage lies in significantly reduced binding affinity to IGF-binding proteins (IGFBPs)—approximately 1/50 that of native IGF-1—resulting in substantially prolonged in vivo half-life (approximately 20-30 hours) and significantly enhanced bioavailability. Furthermore, IGF-1 LR3 effectively crosses the blood-brain barrier, exerting neurotrophic and neuroprotective effects within the central nervous system.

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Material identity

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Storage guidance

Store unopened material in its original sealed packaging, protected from light, moisture, and repeated temperature changes. Follow the product label and batch document for the exact storage temperature. After opening or preparation, use only a validated laboratory storage protocol.

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IGF-010.1 mg x 10 vials