Proteins and hormones1 specification

IGF-DES

Name: IGF-DES
Brand: SUN Peptides
SKU: IGD

COA on request

IGF-DES is a localized growth factor designed for targeted muscle development. Unlike systemic variants, it acts locally on specific muscle groups to support rapid repair and growth. Often used pre- or post-workout, it is favored for addressing weak points or evening out muscle imbalances.

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Selected SKU: IGD
Pack: 2 mg x 10 vials
Status: Available for inquiry

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Purity≥95%Estimated delivery: within one week after the order is placed.

COA is available on request

COA files are available in the document library; additional batch-specific documentation can be requested with your inquiry. Each batch is tested with HPLC purity analysis (≥95%). For MSDS or detailed storage protocols, please contact our sales team.

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DeliveryWithin one week after order

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DocumentationCOA available on request

Research effects

Insulin-like growth factor-1 DES (IGF-1 DES, also known as DES(1-3)-IGF-1) is a naturally occurring truncated variant of IGF-1, lacking the first three N-terminal amino acids (glycine-proline-glutamic acid), resulting in significantly enhanced biological potency. This peptide demonstrates highly targeted efficacy in promoting localized muscle hypertrophy and accelerating tissue repair, particularly suitable for inducing pronounced anabolic responses in areas of local injection. Users report IGF-1 DES is notably effective in accelerating recovery following muscle injury, and increasing localized muscle volume and strength. Its rapid onset of action and localized properties make it of research interest in sports medicine and rehabilitation.

Research mechanism

IGF-1 DES binds to the IGF-1 receptor (IGF-1R) with affinity comparable to native IGF-1, but exhibits approximately 1/10 the binding affinity for insulin-like growth factor-binding proteins (IGFBPs). This characteristic prevents it from being sequestered by IGFBPs in tissues, significantly increasing free active concentration and local bioavailability at target sites. Unlike IGF-1 LR3, IGF-1 DES has a short half-life (approximately 10-20 minutes). This rapid clearance profile confines its actions predominantly to the injection site, enabling precise localized effects rather than systemic actions. Its downstream signaling pathways include PI3K/Akt and MAPK/ERK, promoting local protein synthesis and satellite cell activation while inhibiting the expression of muscle-specific E3 ubiquitin ligases (including atrogin-1 and MuRF1), thereby reducing protein degradation.

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IGD2 mg x 10 vials